The ingredient list matters more than the brand name on the box. Every lubricating eye drop we carry is preservative-free—no BAK, no exceptions. Below you'll find options for mild dryness, moderate symptoms, nighttime relief, and even a spray for those who struggle with drop application.


Why Preservative-Free?

Preservatives like benzalkonium chloride (BAK) can damage the corneal surface with repeated use. For anyone using drops more than 4× daily—or wearing contact lenses—preservative-free is the standard of care.

Which Drop Matches Your Symptoms?

Watery eyes with burning? You likely need lipid support (Thealoz Duo). Gritty, sandy feeling? Hyaluronic acid drops like Hylo work well. Severe overnight dryness? Try a gel like Thealoz Duo Gel before bed.


How Do These Eye Drops Compare?

Product Key Ingredient Best For Duration Contact Lens Safe
Thealoz Duo Trehalose + Hyaluronic Acid Moderate to severe dry eye, MGD 4-6 hours Yes
Hylo Sodium Hyaluronate 0.1% Mild to moderate dryness 2-4 hours Yes
Thealoz Duo Gel Trehalose + Carbomer Gel Nighttime / severe dryness 6-8 hours No (use before bed)
Zaspray Liposomal Spray MGD, lid margin therapy 2-3 hours Yes (closed-eye spray)
I-Drop Pur Hyaluronic Acid (viscoadaptive) All-day comfort, contact lens rewetting 3-5 hours Yes

Frequently Asked Questions

Can I use these drops with contact lenses?

Most preservative-free drops are contact lens safe. Thealoz Duo, Hylo, I-Drop Pur, and Zaspray can all be used with contacts. The exception is Thealoz Duo Gel—its thicker formula is meant for bedtime use without lenses.

How often should I use lubricating eye drops?

For mild dryness, 2-4 times daily is typical. Moderate symptoms may need drops every 2-3 hours. With preservative-free formulas, there's no upper limit—use as often as needed for comfort.

What's the difference between drops and gels?

Drops are thinner and absorb quickly—ideal for daytime use. Gels are thicker, last longer, but can blur vision temporarily. Most people use drops during the day and gel at bedtime for overnight protection.

Why is trehalose helpful for dry eyes?

Trehalose is a natural sugar that forms a protective matrix over corneal cells, helping them retain moisture even under stress. Research published in Clinical Ophthalmology (2017) showed trehalose-based drops improved symptoms in 80% of dry eye patients after 4 weeks.

I can't put drops in my eyes—what are my options?

Zaspray is a liposomal spray applied to closed eyelids. The lipids migrate into the tear film when you blink. It's a good option for children, elderly patients, or anyone who struggles with traditional drop application.